Clinical research compared the candesartan ester with hydrochlorothiazide in the patients of hypertension with obesity antihypertensive effect, candesartan ester piece in addition to have the same blood pressure hydrochlorothiazide effect, also increase insulin sensitivity in patients with, the sympathetic nerve inhibition.

24 hours ambulatory blood pressure monitoring found that candesartan ester in reducing high blood pressure early in the morning and in the early morning blood pressure better than angiotensin converting enzyme inhibition (AcEI). Candesartan ester low incidence of adverse reactions and mild, and increases with the increase of the dose.

Candesartan ester can according to the different situation of patients, with combination of different medicines. Diabetic nephropathy is a long-term glucose metabolic disorder lead to glomerular basement membrane thickening, renal microcirculation, increase glomerular filtration pressure, increased urinary albumin excretion. Because of early kidney disease clinical symptom is not obvious, once in clinical kidney disease, often develop rapidly and eventually lead to chronic renal failure, is one of the leading causes of death among patients, and pancreatic peptidase and candesartan ester joint application with synergy, more effectively reduce urinary protein excretion, with reduced urinary protein excretion can reduce glomerular damage, retard diabetic kidney disease, chronic renal insufficiency, better protection of renal function.

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